Shenzhen Mikon Biotechnology Co.,Ltd

Teriparatide mediates bone metabolism by inhibiting osteoblast apoptosis, activating bone lining cells, and enhancing osteoblast differentiation. By regulating the adenylyl cyclase-cyclic adenosine monophosphate-protein kinase A pathway, it intermittently stimulates the PHT-I receptor on the surface of osteoblasts, bone lining cells and bone marrow stromal stem cells, promotes the differentiation of osteoblasts and prolongs the life of osteoblasts. Stimulates the proliferation of osteoblast cell lines through the phosphate C-cytosolic calcium-protein kinase C signaling pathway; By inhibiting the transactivation activity of PPARγ, the differentiation of stromal cells into adipocyte lines was reduced, and the number of osteoblasts was increased. Indirect regulation of bone growth by modulating cytokines, for example, iGF-1 can be induced to bind to osteoblasts, thereby promoting bone formation; The process of bone formation is regulated through the Wnt signaling pathway, thereby increasing bone formation.